Local anesthetics may be injected or topically applied to skin and mucosal membranes. Systemic toxicity may occur from administration of local anesthetics and is related to the serum concentration of the drug as it is absorbed into the circulation. This serum concentration is influenced by the dose, site, and method of drug administration (Berde & Strichartz, Butterworth et eds, Catterall & Mackie, Curtis et al, Rosenberg et al, Schwartz & Kaufman). Max volume of 1% lidocainethat can be administered to a 10 kg patient = 45 mg / 10mg/mL = 4.5 mL.for 1% lidocaine: contains 10 mg of lidocaine per 1 mL Depends on concentration (see conversion table below).Maximum volume of lidocaine administered.Total dose that can be used for this patient = 4.5 mg/kg x 10 kg = 45 mg.Maximum dose of lidocaine (plain, without vasoconstrictor) is 4.5 mg/kg (not to exceed 300 mg).Quick reference by example (see more detailed information below): Example calculation - Lidocaine when administered without vasoconstriction
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